You should try to get a good night sleep much work you have to do.
A. however
B. whatever
C. no matter
D. although
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(答案→)A. however
B. whatever
C. no matter
D. although
解析：句意：无论你有多少工作要做，你应该保证有充足的睡眠。However /no matter how可以引导让步状语从句，结构是：However/no matter how+adj/adv.+主语+谓语，B项whatever应该接名词，C项少了how，D项although不能接倒装句，选A。