His partner left the pany, it more difficult for him to run it.
A makes B make C to make D making
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解析：本题应选非谓语动词，用现在分词作结果状语。现在分词做结果状语表示自然而然的结果，而不定式表示意料之外的结果。如：His parents died , leaving him an orphan. 父亲去世了，（结果）他成为孤儿。Tom got to the station only to find the train had gone.汤姆到达车站，却发现火车已经开走了。