The old couple has two children, __________ able to e to see them when they feel lonely, however.
A.both of them are
B.neither of them are
C.none of whom are
D.neither of whom
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D解析考查定语从句。句意：这对夫妇有两个孩子，然而，当他们感到孤独的时候没有一个能来看他们。根据句意可排除A ,由two children可排除C ，B表达不正确，所以选D。