In case of emergency, whether knowing how to apply first aid or not really ________ in matters concerning wounds like swollen wrists, broken arms, burns, cuts, and so on.
A.makes difference
B.makes a difference
C.makes differences
D.makes different
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B解析试题分析：考查固定词组，make difference意思“有不同”，make different意思“将某物与某物区分”，makes a difference意思“有影响”，句子意思“万一有紧急情况，是否知道怎样提供急救对于关系像红肿手腕、骨折、烧伤、刀口等创伤有很大影响”，所以选B考点：考查固定词组点评：注意固定句型In case of意思“万一”，句子 whether knowing how to apply first aid or not really…，是whether引导的主语从句，主语从句中又含有how引导的宾语从句。动名词concerning做名词matters后置定语。