the progress of science and technology, the disfort of old age will no doubt always be with us.
A. As for
B. In addition to
C. Except for
D. In spite of
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A. As for
B. In addition to
C. Except for
(答案→)D. In spite of
解析：考查词组：A. As for至于，B. In addition to此外，C. Except for 除了（整体的说明，局部排除）D. In spite of虽然，句意：虽然有科技的进步，但是老年的不适毫无疑问是会永远和我们在一起的。选D。