I really appreciate ________ a great effort to e to help me with the problem．
A.your making
B.you to make
C.you to make
D.your being made
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A解析句意是“对于你帮助我解决这个问题所作出的努力我真得十分感激”。appreciate后面接动名词短语作宾语。此处表主动意义，故选A项。后面只能接动名词作宾语的动词有mind，miss，enjoy，give up，admit，finish，escape，practise，avoid，keep，suggest，imagine，can’t help等。