The seriously ill man thinks it doesn’t matterhe will die, but what matters much is how he

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A. how
B. that
C. why
D. what
解析：选A。考查主语从句。句意: 这位病情严重的人认为怎么死没有关系, 而重要的是他如何活着。根据后面的句式but what matters much is how he lives推知前面意思为“如何”与后面的how he lives匹配。