One Friday,we were packing to leave for a weekend away my daughter heard cries for help A.

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A. after
B. while
C. since
D. when
解析：D【命题动向】考查状语从句。
解析一：根据固定搭配：be doing sth… when…，正在做某事突然……，符合文意，when在句子中引导时间状语从句。
解析二：句意为：“一个星期五，我们正在打点行装要动身去度周末，就在那时，我女儿听到了呼救声”四个选项中只有“when”可作并列连词，表示“就在那时”，且前一分句常用于固定的时态：was／werc doing；had done；was／were about to do…等。故答案为D项。