Scientists across the world agree that this is an invention of _______ great significance, _______ invention that will greatly change human life.A.a; theB.a; anC./ ; theD./ ; an
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D解析考查冠词。Of great significance,固定短语，意义重大的，介词后一般不加冠词。结合上文an invention一项发明，本句和前文为并列表语，泛指任何一项发明，故用不定冠词，词首音素为元音，故选D。