Now that smoking great harm to you and people around you, you might as well .A. does; give

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(答案→)A. does; give it up
B. does; give it in
C. makes; give it up
D. makes; give it in
解析：考查词组：第一空填does，do great harm to给…带来很大的伤害，第二空是give up放弃，give in屈服，让步，句意：现在抽烟对你和周围的人有很大的伤害，你最好戒掉。选A。