There are too many difficulties for us . We really don’t know to do.
A. to deal with, what
B. to deal with, how
C. to do with, how
D. to do with, what
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(答案→)A. to deal with, what
B. to deal with, how
C. to do with, how
D. to do with, what
解析：根据题意第一空deal with的动作发生在谓语动词之前，故用不定式，第二空考查疑问词+不定式做宾语。句意：对于我们来说有好多问题要处理，我们真的不知道怎样处理。故选A。