If you work with a strong will, you can overe any difficulty, ________ great it is.A.no matterB.whatC.howeverD.Whatever
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C解析句意：如果你非常想做这项工作，你就可以克服一切困难，无论困难有多大。可直接排除A项，因no matter后需加what, how, where等关系词；设空处后是形容词great，可排除B、D两项；however=no mater how无论多么。