Besides, well it is translated, the spirit of the original work is lost.
A. no matter how
B. no matter what
C. no matter when
D. no matter where
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(答案→)A. no matter how
B. no matter what
C. no matter when
D. no matter where
解析：A 考查让步状语从句。句意为：无论作品翻译得有多好，可它原始的精髓却没有了。故A项正确。