【小题1】 She often does her homework at weekends. (改为一般疑问句)
Does; do she often What time her homework at weekends？
【小题2】The children do after-school activities at 4p.m. (就划线部分提问)
doesn’t go Which man do the children do after-school activities?
【小题3】My son goes to the English Club every Tuesday. (改为否定句)
My sonby bus to the English Club every Tuesday.
【小题4】The man in a white shirt is my father.(划线部分提问)
is your father?
【小题5】The little girl takes a bus to school every morning. (改为同义句)
The little girl goes to school every morning.
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解析：
【小题1】一般现在时变一般疑问句，将助动词提前，所以，第一个空填Does；动词用原形，所以第二个空用does的原形do。
【小题2】at 4p.m“在下午4点”，所以提问的是时间，要用What time。
【小题3】本句变否定句应该借助助动词，My son是第三人称单数，所以应该用doesn’t；does后面要用原形，所以要用goes的原形go。
【小题4】原句的意思是“穿白色衬衫的男子是我爸爸.”应该问“哪个是你爸爸？”所以应该用Which man。
【小题5】take a bus to school与go to school by bus同义，是“乘公共汽车去上学”。