The house I grew up has been taken down and replaced by an office building.
A. in it B. in C in that D in which
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解析：通过分析句子结构， the house （ I grew up in ） has been taken down and replaced by an office building ，括号里是定语从句，本来应该是 I grew up in the house ，先行词the house 在从句中作宾语，是物，应该要用which或that指代。但是先行词作宾语可以省略。其实整句完整应该是the house that/which I grew up in has been taken down and replaced by an office building D的顺序放错了，D的语序应该是..the house in which I grew up has been taken down and replaced by an office building。可知选B