Jim was so badly burnt that at first they began to of his life.
A. despair
B. designate
C. disappoint
D. despise
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(答案→)A. despair
B. designate
C. disappoint
D. despise
解析： despair of (=be in despair) 对.......失望：1) Don't despair: things will get better soon. 2) He began to despair of success. 3) He despaired of being able to repair the TV set. (他对能否修好这台电视机表示失望。) designate指明, 指出, despise 轻视, 藐视。