Don’t throw litter around. Please.A. pick it upB. pick up itC. pick up themD. pick them up

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(答案→)A. pick it up
B. pick up it
C. pick up them
D. pick them up
解析：本题的含义是不要乱扔垃圾，请把它捡起来，pick sth up表示把某物捡起来，sth为代词必须放在两者之间，前句使用litter，故用it来代替，故本题选A。