I had tomy little sister when my mother was not at home.A. look forB. look afterC. look at

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A. look for
(答案→)B. look after
C. look at
D. look into
解析：本题的含义是当我的母亲不在家的时候，我得照顾我的妹妹，look after表示照顾的含义，故本题选B。其它短语的意思分别为look for 寻找，look at看一看，look into窥视，意思不符合句意，故不选。