---Alison, I’m sorry. I can’t e to the wedding with you tomorrow morning.---______? -- My grandma was severely ill, so I have to stay in the hospital to look after her.A.How is itB.How eC.So whatD.What’s the problem
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B解析考查交际用语。How is it它好吗?How e为何会呢?So what那又怎么样?What’s the problem问题怎么了,句意:艾丽斯,很抱歉,明天早晨我不能和你一起去参加婚礼了。为何会呢?我的奶奶病的很严重,因此我不得不呆在医院照顾她。所以选B。