_____difficulty we will face, we should have confidence and try to solve it.
A.However
B.No matter how
C.Whatever
D.Whenever
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C解析考查状语从句。因为difficulty是名词，所以只能选用whatever。 However和no matter how只能放在形容词前。 Whenever表示的是时间。句意为无论我们将会面临什么困难，我们都应当有信心并且尽量解决它。