She for the professor who was ill.
A. substituted
B. changed
C. shifted
D. replaced
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(答案→)A. substituted
B. changed
C. shifted
D. replaced
解析：动词辨析. A. 代替;取代 B. 改变 C. 转移;替换 D.取代；替换。replace 和substitute都可作动词，但用法不一样，一般搭配是replace A with B 用B来代替A；substitute A for B 用A来代替B 。故选A。