—What shall we do this weekend? — .Whatever you wantA. It's up to youB. I couldn't agree

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(答案→)A. It's up to you
B. I couldn't agree more
C. No problem
D. It depends
解析：A由你决定；B我非常同意；C没问题；D看情况而定；句义：—这个周末我们干什么？—由你决定，你想做什么就做什么。根据后半句的Whatever you want，可知周末的事情任由对方决定。故A正确。