---We haven’t heard from Mary for a long time．---What do you suppose ______ her?A.the matter is withB.is the matter withC.was happening toD.have happened to
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B解析do you suppose是插入语，主语应为what，选项部分应用作句子的谓语部分。根据句意，该句应表达为What is the matter with her?或What has happened to her? A项为语序错误，C项为时态错误，D项为主谓一致错误。