My sister has some trouble spelling some of the words in American English, while I have some difficulty my pronunciation．
A. with; with
B. in; with
C. with; in
D. in; in
网友回答
A. with; with
(答案→)B. in; with
C. with; in
D. in; in
解析：考查短语中介词搭配的区别。have trouble/difficulty with sth．/(in)doing sth．做某事有困难,特别注意in后面接Ving；with后面接名词，从题干来看，第一空后是spelling，要选in；第二空后是my pronunciation为名词，选with；故B正确。