This is the housemy grandma lived twenty years ago.A. in thatB. in whichC. thatD. 不填

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A. in that
(答案→)B. in which
C. that
D. 不填
解析：考察定语从句。先行词是the house，定语从句的主语是my grandma,动词是不及物动词live，后面不加宾语。故句子很完整，要使用关系副词where,这里的where=in which.故B正确。