(2013·烟台高三二模)It was a difficult job for him.He had tried everything but it made little .A.

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A. use
B. good
(答案→)C. difference
D. result
解析：选C　考查名词辨析。句意：这项工作对他来说有点难，他做了各种各样的努力，但没有什么成效。make a difference“起作用；有影响”，此处的make little difference表示“没有多大作用”，符合题意。