Many things that were once considered useful and , for example, tobacco, is now thought ha

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(答案→)A. beneficial
B. suitable
C. fulfilling
D. accessible
解析：句意:曾经被认为是有用和有益的东西，比如烟草，现在被认为是有害的。Beneficial有益的；suitable适当的；fulfilling令人高兴的；accessible易接近的。根据句意故选A。