If you don't go after what you want, you will never have .A. oneB. itC. themD. these

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A. one
(答案→)B. it
C. them
D. these
解析：B 考察代词。句意为：如果你不去追逐你想要的，你就永远不会得到它。It既可以指代可数名词也可以指代不可数名词；them只能指代可数名词复数形式。此次的it指代前面的what you want。故B正确。