I have problems many things. For example, I have problems learning Maths well.
A. with, in
B. about, with
C. in, with
D. in, about
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(答案→)A. with, in
B. about, with
C. in, with
D. in, about
解析：考查固定句型。“做某事有困难”have problems with sth.= have problems (in) doing sth.其中的problem还可以换成difficulty，trouble等词；句意“我有很多难题，比如，我数学学不好。”故选A。