It's not what you do once in ____ while but what you do day in and day out that makes ____ difference.
A.the ; /
B./ ; a
C.a; a
D.the; a
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C解析考查冠词。固定词组in a while=in a moment=in a minute=soon=at once=right away 立刻 马上；make a difference有影响，起作用；day in and day out每天，一天又一天；本题是一个强调主语的强调句型。句意：起作用的不是你马上要做的事情而是你每天所做的事情。