From the expression on his face we can guess something must have happened to him.A. conf

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(答案→)A. confused, confusing
B. confusing, confused
C. confused, confused
D. confusing, confusing
解析：考查形容词：confused感到困惑的，修饰人或和人有关的表情，笑容等，confusing令人困惑的，一般修饰物，第一空修饰expression用confused，第二空修饰something用confusing，句意：从他脸上困惑的表情我们可以猜出他一定发生了很令人困惑的事情。选A。