its positive or negative effect, change can be stressful.
A. Apart from
B. except for
C. In spite of
D. Regardless of
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A. Apart from
B. except for
C. In spite of
(答案→)D. Regardless of
解析：句意：不管是肯定还是否定的影响，变革是有压力的。apart from除了……之外；except for除了；in spite of尽管；regardless of不管。根据句意故选D。