As is known to all his friends, would over discourage him because he would never give up

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A. something
B. anything
C. everything
(答案→)D. nothing
解析：
试题分析:考查不定代词用法。A 某物；B 任何事物；C 一切事物；D 没有什么。从he would never give up可知他不会放弃，所以前句应该是没有什么可以阻止他，nothing表达否定意思，所以D选项正确。句意：他的朋友们都知道，没有什么能阻止他，因为他永远也不会放弃他当导演的梦想。