_________ you may have, you should gather your courage to face the challenge
A.Whatever serious a problem
B.However serious a problem
C.However a serious problem
D.No matter how a serious problem
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B解析试题分析：考查让步状语从句：句意：无论你可能遇到多么严重的问题，你都要鼓足勇气面对挑战。Whatever后面接名词，排除A。however/no matter how后面可以接adj+冠词+名词，CD都是错的，选B。考点：考查让步状语从句