I knew that would ever discourage him; he would never give up wanting to be a director. A

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A. something
B. anything
C. everything
(答案→)D. nothing
解析：考查不定代词的用法。句意为“我知道没有什么能够阻止他；他决不会放弃做一名导演的念头。”根据后面“never give up”可知前面相应地也要用否定性的不定代词nothing。